NAD+ Therapy for Cellular Energy, Longevity, and Whole-Body Wellness in Sherman, TX
1. The Foundation of Wellness: What Is NAD+ Therapy?
Author: Quyen Johnson, FNP-C
1. The Foundation of Wellness: What Is NAD+ Therapy?
At One Family Clinic & Urgent Care in Sherman, Texas, we take a thoughtful, forward-looking approach to health, one that honors the strengths of traditional medicine while embracing the promise of advanced wellness. That balance is exactly why NAD+ Therapy has become such an exciting part of the conversation.
NAD+ (Nicotinamide Adenine Dinucleotide) isn’t a drug or a vitamin. It’s a naturally occurring coenzyme present in every single cell of your body, and one of the most essential players behind the scenes. NAD+ supports how your cells create energy, repair themselves, and function at their best on a metabolic level.
NAD+ Therapy is centered on replenishing healthy NAD+ levels, helping your body restore cellular energy production, support DNA repair, and promote overall metabolic health, right where it all begins: at the cellular level [1].
The Critical Roles of NAD+
NAD+ is essential to life and long-term health because it serves as a vital “helper molecule” for proteins that regulate your body’s most fundamental biological processes. In many ways, it quietly supports the systems that keep you functioning, adapting, and healing every single day.
At a cellular level, NAD+ plays several critical roles:
- Converting nutrients into usable cellular energy (ATP):
Through a process called the electron transport chain, NAD+ helps your body transform food into energy. This is how every action, from a steady heartbeat to a clear thought, gets powered. - Supporting mitochondrial function:
Mitochondria are often called the “power plants” of your cells, and for good reason. NAD+ serves as the fuel that powers these power plants, helping your cells meet daily energy demands. - Activating enzymes linked to longevity and cellular repair:
NAD+ is the exclusive co-substrate for two crucial enzyme families: sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs) [1]. These enzymes are often described as the “guardians of the genome” because they help regulate DNA repair, manage cellular stress, and influence the aging process. - Maintaining healthy brain and nervous system function:
Healthy NAD+ levels support neurotransmitter production and help protect brain cells, which can translate into stronger cognitive function and mental clarity.
In essence, NAD+ is the currency of cellular health. When NAD+ levels are robust, your cells are better equipped to produce energy efficiently and repair damage effectively, laying the groundwork for resilience, vitality, and long-term wellness.
NAD+ and the Science of Cellular Longevity
To truly appreciate the potential of NAD+ Therapy, it helps to look a little deeper, down to the level where aging actually begins: the cell. Researchers have identified twelve core cellular changes, often referred to as the “hallmarks of aging,” that drive age-related decline [3]. What’s especially compelling is that NAD+ is directly involved in regulating several of these foundational processes.
The Sirtuin Connection
One of the most well-studied relationships in longevity science is the connection between NAD+ and a family of proteins called sirtuins. Sirtuins act as cellular stress sensors, helping regulate DNA repair, gene expression, and metabolic balance. They’re often nicknamed “longevity genes” because they’re activated by practices like caloric restriction and exercise—two interventions consistently linked to longer lifespan across multiple species.
Here’s the critical piece: sirtuins cannot function without NAD+ [1]. They rely on it entirely as a co-substrate. When NAD+ levels decline, sirtuin activity slows, and the cell’s ability to protect and maintain itself is compromised. This can affect the cell’s ability to:
- Repair DNA damage: Unrepaired DNA damage is a major contributor to aging and chronic disease.
- Regulate metabolism: Sirtuins play an important role in keeping blood sugar and fat metabolism balanced.
- Maintain mitochondrial health: They help ensure mitochondria are working efficiently and assist in clearing out damaged ones.
By restoring NAD+ levels, we’re essentially supplying the fuel these longevity pathways need to function again, helping cells respond more effectively to stress and repair themselves over time.
The Role of NAD+ in DNA Repair
NAD+ is also essential for another critical repair system involving enzymes called PARPs (Poly(ADP-ribose) Polymerases) [1]. PARPs are responsible for detecting and repairing single-strand breaks in DNA. When damage occurs, these enzymes rush to the site and consume significant amounts of NAD+ to initiate repair.
If NAD+ levels are already low, this repair process becomes less efficient. Over time, unrepaired damage can accumulate, contributing to cellular dysfunction, another defining hallmark of aging.
Research into NAD+ continues to expand, particularly in areas such as aging, metabolic health, and neuroprotection. At One Family Clinic, we stay closely connected to this evolving science so we can offer care that’s thoughtful, evidence-informed, and aligned with the goal of long-term cellular health and vitality.
2. Why Do NAD+ Levels Decrease Over Time?
Why would anyone ever need support to boost NAD? The simple answer is this: NAD+ levels naturally decline as we age. In fact, by middle age, NAD+ levels may drop by as much as 50% compared to our younger years [2]. This decline is considered a hallmark of the aging process and is closely associated with the development of many age-related concerns.
And it isn’t just the passing of time at work. NAD+ is actively used up by the very repair processes it helps power. Every day, your body relies on NAD+ to respond to stress, repair damage, and maintain balance, and over time, that demand adds up. Several factors can accelerate the depletion of NAD+, including:
- Natural aging: The primary driver of NAD+ decline, as the body produces less while consuming more to maintain cellular function.
- Chronic stress: Ongoing stress triggers hormonal and cellular responses that rapidly drain NAD+ reserves.
- Poor sleep: Without restorative sleep, the body’s ability to regenerate and replenish NAD+ is significantly impaired.
- Inflammation: Chronic, low-grade inflammation forces the body into a constant repair mode, depleting NAD+.
- Environmental toxins: Exposure to toxins increases the demand for NAD+ as cells work harder to detoxify and repair damage.
- Metabolic dysfunction: Conditions such as insulin resistance can disrupt the delicate balance of NAD+ metabolism.
When NAD+ levels fall, cells become less efficient at producing energy and repairing themselves. This slowdown is why NAD+ has become a central focus in preventive and longevity-oriented wellness care. As cellular energy production declines, many people experience chronic fatigue, mental fog, and a gradual loss of vitality; symptoms often dismissed as “just getting older,” even though they don’t have to be.
3. Potential Benefits of NAD+ Therapy
NAD+ Therapy is not intended to treat or cure disease. Instead, it’s a wellness-focused approach designed to support your body’s natural cellular processes. By replenishing this essential coenzyme, the goal is to help your cells function more efficiently, often in ways that feel more energetic, resilient, and youthful.
While individual experiences can vary, patients at One Family Clinic & Urgent Care often explore NAD+ Therapy for support in the following areas:
- Improved cellular energy & reduced fatigue:
This is one of the most commonly reported benefits. By fueling the mitochondria, NAD+ helps restore the energy reserves your body relies on for everyday life. - Enhanced mental clarity, focus, and memory:
NAD+ supports brain cell health and neuroprotection, which many patients notice as reduced “brain fog” and sharper cognitive function. - Support for healthy aging & longevity pathways:
Through activation of sirtuins and PARPs, NAD+ helps the body manage cellular stress and repair DNA damage, key mechanisms at the center of longevity science. - Improved metabolic and mitochondrial function:
More efficient cellular metabolism can support weight management and contribute to overall systemic health. - Better sleep quality and stress resilience:
By helping the body respond more effectively to cellular stress, NAD+ may promote a more balanced nervous system and deeper, more restorative sleep. - Overall vitality and wellness optimization:
Many patients describe a general sense of well-being, improved mood, and greater physical endurance—subtle shifts that can make a meaningful difference in daily life.
Taken together, these potential benefits are why NAD+ Therapy has become a popular option for individuals looking to optimize wellness, support healthy aging, and feel more like themselves again.
4. Who May Be a Good Candidate for NAD+ Therapy?
NAD+ Therapy is well suited for individuals who take a proactive, intentional approach to their health and are looking to optimize how their bodies function, now and in the years ahead. It’s best viewed as a supportive tool within a comprehensive, values-driven wellness plan.
You may consider NAD+ Therapy if you:
- Feel chronically fatigued despite making positive lifestyle changes such as improving diet, exercise, and sleep.
- Are interested in healthy aging and longevity support and want to invest in your long-term cellular health.
- Want to optimize mental and physical performance, whether for work, athletics, or the demands of everyday life.
- Experience brain fog or a noticeable decline in cognitive sharpness that affects focus or productivity.
- Take a preventive approach to wellness and are seeking thoughtful, evidence-informed therapies at the forefront of modern care.
Because no two people are exactly alike, a personalized consultation is an essential first step. At One Family Clinic & Urgent Care, we treat every patient like a member of our extended family, which means taking the time to understand your goals, review your medical history, and ensure that any therapy we recommend is truly the right fit for you.
Our Patient-Centered Process
Your journey toward enhanced cellular health begins with a thoughtful, personalized approach, one that prioritizes listening, safety, and clarity every step of the way.
- A comprehensive wellness consultation:
You’ll meet with one of our providers to review your health history, current concerns, and long-term wellness goals. We take the time to listen closely, because understanding your story is essential to creating meaningful, effective care. - Thoughtful review of health history and goals:
Together, we’ll review any relevant lab work and discuss how NAD+ Therapy may fit into your overall health picture. - A customized wellness plan:
Based on your unique needs and goals, we’ll design a personalized NAD+ protocol, including dosage and frequency, with the intention of supporting the outcomes that matter most to you.
Safety and Transparency
Although NAD+ is a naturally occurring molecule in the body, the infusion process must be handled with care. Some patients may experience mild, temporary side effects, such as flushing and nausea.
Our commitment is to safe, ethical, and evidence-informed wellness care, never a one-size-fits-all approach. We believe in next-level care that blends compassion with clinical precision, always using the latest research to help you move toward the outcomes you’re seeking with confidence and trust.
Frequently Asked Questions about NAD+ Therapy
NAD+ plays a foundational role in cellular health. It helps your cells produce energy, repair DNA, and regulate key metabolic and longevity pathways. As a critical coenzyme, NAD+ allows your mitochondria (your cells’ energy producers) and sirtuins (enzymes linked to healthy aging) to function as they should.
When guided by trained medical professionals, NAD+ Therapy is generally considered safe as part of a wellness-focused program. At One Family Clinic & Urgent Care, we carefully screen every patient and closely monitor the treatment process to prioritize both safety and comfort.
Some individuals notice an initial boost in energy or mental clarity within days or weeks of their first few sessions. That said, many of the most meaningful benefits, especially those related to cellular repair and longevity, tend to develop gradually over time. Consistency and patience often make the biggest difference.
Not necessarily. While NAD+ Therapy can be highly supportive for many people, it isn’t a universal solution. A personalized consultation is essential to determine whether it aligns with your health goals, medical history, and current medications. We are committed to recommending only what is truly in your best interest, nothing more, nothing less.
NAD+ Therapy in Sherman, Texas
- Sherman
- Denison
- Pottsboro
- Howe
- Van Alstyne
- Whitewright
- Gunter
- And all surrounding North Texas communities.